Synthesis of Novel 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine Derivatives and In-vitro Evaluation of their Antitumor and Antibacterial Activities

Benzoxazole is one of the biologically important heterocyclic compounds, which shows remarkable pharmacological activities. In this work, 3-methyl-1-(5-methyl-1,3-benzoxazol-2-yl)-1H-pyrazol-5-amine derivatives have been synthesized by using mild protocol under solvent free condition. Structures compounds confirmed through IR, 1H NMR, 13C NMR and Mass spectral methods. All were assessed for their antitumor antibacterial 6h has found activity on both studies 6g 6a exhibited promising activity. Simple work up technique, good yield use environmental-friendly reagents are reaching features present work.